, Roberts WN For your privacy and protection, when applying to a job online, never give your social security number to a prospective employer, provide credit card or bank account information, or perform any sort of monetary transaction. . Moreover, a difference between the interRR of the PGA assessed by an untrained physician (0.50.63) and a trained investigator (0.790.81) was found, suggesting the need for PGA scoring training or standardization [36]. , Petri MA , Magder L T1 - Associations between physicians' global assessment of disease activity and patient-reported outcomes in patients with systemic lupus erythematosus. Reviews and case series with fewer than five patients were excluded. government site. Construct validity. Beaton DE Finally, the PGA enables the measurement of disease activity globally compared with a glossary-based index. Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. , Chatzidionysiou K Patient-reported outcomes (PROs) reflect the patient's perspective and are used in rheumatoid arthritis (RA) routine clinical practice. In the absence of a consensus, Aranow [26] found a better correlation between the SLEDAI and the PGA when the latter was assessed taking into account laboratory test results. Strength. Navarra SV et al. PMC et al. Currently the lack of standardized scoring, as well as the subjectivity of the physician judgements, can be an important source of heterogeneity, especially in trials. , Nguyen SC et al. JSS Medical Research. , Kalunian K Unable to load your collection due to an error, Unable to load your delegates due to an error. Objective: The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. http://oml.eular.org/glossary (31 January. 'Not at target': prevalence and consequences of inadequate disease control in systemic lupus erythematosus-a multinational observational cohort study. SLE3. The interRR was assessed in seven studies [4, 10, 11, 36, 65, 68, 94], showing values ranging from 0.67 [68] to 0.96 [94]. , Farewell V In the absence of a well-recognized gold standard for disease activity, criterion validity of the PGA is established when it correlates with a measure that the author of the study defined a priori as the gold standard. 2022 Sep 20;19(19):11895. doi: 10.3390/ijerph191911895. In one study [25], the PGA of disease activity resulted from the combination of the clinical visit, laboratory markers evaluation and the physicians knowledge of the patient disease history. Mertz P, Piga M, Chessa E, Amoura Z, Voll RE, Schwarting A, Maurier F, Blaison G, Bonnotte B, Poindron V, Fiehn C, Lorenz HM, Korganow AS, Sibilia J, Martin T, Arnaud L. RMD Open. et al. , Bertsias G A difference between the interRR of the PGA assessed by an untrained physician (ICC=0.50.63) or a trained investigator (ICC=0.790.81) was found [36]. HHS Vulnerability Disclosure, Help et al. 1 2. , Piette EW Manzi S The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate the intracellular signaling of cytokines in a wide spectrum of cellular processes. , Urowitz MB Unauthorized use of these marks is strictly prohibited. , Gladman DD , Clowse M. Moorthy LN No data were found regarding the feasibility of the PGA. , Lin M It operates in Albuquerque, and New Mexico. The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA. et al. Methods: Criterion validity was assessed exploring the PGA correlation with quality of life measurements, biomarker levels and treatment changes in 28 studies, while no study has evaluated correlation with damage. Gyri N , Suriano A This concept includes content validity, face validity, construct validity and criterion validity. [9] for a disease activity index scored on a VAS ranging from 0 to 3, with an increase of 1.0 since the last visit indicating a flare. Arriens C Face validity was reported in all the articles retrieved in which the PGA was used alone or as part of composite indices (Systemic Responder Index, Safety of Estrogen in Lupus Erythematosus National Assessment Flare Index, Lupus Low Disease Activity State, Definitions of Remission in Systemic Lupus Erythematosus criteria). It was published in 1977 and was initially designed for the measurement of self-assessed pain in rheumatoid arthritis although it has since been used to evaluate RA more globally. Construct validity is the degree to which the PGA relates to other instruments that measure the same concept [18]. If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week's collection. The geographical analysis of the Global Global Respiratory Devices market provided in the report is just the right tool that competitors can use to discover untapped sales and business expansion . The literature search identified 91 studies. SELENA SLEDAI4. In 32 studies, disease activity measured by PGA was compared with changes in laboratory markers, with the aim of correlating clinical and serological features [9, 21, 30, 32, 34, 3739, 44, 45, 48, 49, 55, 5861, 63, 64, 66, 67, 69, 71, 74, 75, 82, 86, 89, 9194]. , Merrill JT. Castrejn I, Ra-Figueroa I, Rosario MP, Carmona L. Reumatol Clin. Myelogram - correct answer NPO for 4-6 hours. For instance, in an analysis of studies of the prevalence of SLE in the Asia-Pacific region, higher rates of renal involvement were observed in Asian patients (21-65% at SLE diagnosis and 40 . Chaigne B , Henriques C , ODell JR Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention. The responsiveness of the PGA was assessed through different methods [109, 113] showing a high sensitivity for detecting clinical variations [84]. [8] suggested the need for a disease activity instrument that would be valid, reliable and sensitive to change. et al. , Anderson N Jesus D , Saad-Magalhes C et al. TOTAL DOCUMENTS. , Pego-Reigosa J-M Schlencker A, Messer L, Ardizzone M, Blaison G, Hinschberger O, Dahan E, Sordet C, Walther J, Dory A, Gonzalez M, Kleinlogel S, Bramont-Nachman A, Barrand L, Payen-Revol I, Sibilia J, Martin T, Arnaud L. Lupus Sci Med. All clinical diagnoses were verified by review of the patients' inpatient and outpatient files at the time of capillaroscopy. Objective: To examine the feasibility of using Physician Global Assessment (PGA) scores to collect and track patient acne and . Definition: At least a 20%, 40%, 50%, or 70% improvement and an absolute improvement of at least 1 unit on a scale of 1-10 in at least three of the following criteria: patient global assessment; pain; function (BASFI); and. , Petri M. Thanou A , Sayedbonakdar Z Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease that can occur with or without systemic lupus erythematosus (SLE). , Sengupta M , Buyon J , Leung HW RMD Open 2018;4:e000578. , Magder LS The search strategy for SSc-related publications identified 75 citations . , Adamichou C The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients age. official website and that any information you provide is encrypted Criterion validity also refers to the degree to which an instrument predicts aspects and phenomena occurring in the future [108]. et al. Provide oversight to Shared Services Derivatives team supporting RWA operations and production. Background: Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. , Burlingame RW We have systematically reviewed all studies about validation of the PGA in SLE. , Sadovici-Bobeica V Physician global assessments for disease activity in rheumatoid arthritis are all over the map!. Reliability. et al. The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. Over the years, PGA-IGA scales were modified for the purpose of clinical settings and thus present a diversity in the number of response options (4 to 10 points), the response options label and the . Copay AG Systemic lupus erythematosus (SLE), is the most common type of lupus. For permissions, please email: journals.permissions@oup.com, This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (. , Voskuyl A , Socher SA 2. Kandane-Rathnayake R, Louthrenoo W, Hoi A, Luo SF, Wu YJ, Chen YH, Cho J, Lateef A, Hamijoyo L, Navarra SV, Zamora L, Sockalingam S, An Y, Li Z, Katsumata Y, Harigai M, Hao Y, Zhang Z, Kikuchi J, Takeuchi T, Basnayake BMDB, Chan M, Ng KPL, Tugnet N, Kumar S, Oon S, Goldblatt F, O'Neill S, Gibson KA, Ohkubo N, Tanaka Y, Bae SC, Lau CS, Nikpour M, Golder V, Morand EF; Asia-Pacific Lupus Collaboration. Published by Oxford University Press on behalf of the British Society for Rheumatology. Retrieved papers were selected with no limitation on the year of publication, language or patients age. SLE has protean and often complex manifestations, necessitating careful clinical assessment. AU - Kandane-Rathnayake, Rangi. et al. et al. Published by Oxford University Press on behalf of the British Society for Rheumatology. There is no cure for lupus, but medical . Gladman DD Background Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. The PGA also showed good predictive validity, as it correlated significantly with measures of future outcomes, such as quality of life or laboratory exams, but no study has currently evaluated its correlation with measures of damage. Ann Rheum Dis 2 Isenberg DA, Allen E, Farewell V, et al. , Ho LY LECTURE 10: MEDICAL SURGICAL NURSING. Cloud, mobility, security, and more. , Friebus-Kardash J Identification of new candidate drugs for primary Sjgrens syndrome using a drug repurposing transcriptomic approach, When it looks like Behets syndrome but is something else: Differential diagnosis of Behcets syndrome: a two-centre retrospective analysis, Huge water-balloons in the belly: multiple pancreatic pseudocysts in systemic lupus erythematosus, A randomized, double-blind, placebo-controlled, parallel group study on the effects of a cathepsin S inhibitor in primary Sjgrens syndrome, How to plug the leaky pipeline in clinical rheumatology across Europelessons to be learned from experiences in business, About the British Society for Rheumatology, British Society for Rheumatology Journals, https://doi.org/10.1093/rheumatology/keaa383, https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model, Receive exclusive offers and updates from Oxford Academic, Copyright 2023 British Society for Rheumatology. How should lupus flares be measured? , Patrick DL disease activity). This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. SLE is an immune-mediated multisystemic disease characterized by a wide variability of clinical manifestations and a course frequently subject to unpredictable flares [1, 2]. , Alarcn GS They proposed a physician global score on a 10cm visual analogue scale (VAS) to be used as a gold standard to compare six disease activity instruments [4]. The correlation with the SLEDAI was determined in 12 studies (Fig. The results are similar, and less than half the time is required for scoring. Construct validity was demonstrated by a good correlation (r 0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). Your recommendations as to what might or should be done in relation to various issues observed. Karol DE , Magder LS Whenever papers reported duplicate data, the most recent article was selected. However, it is important to remember that not all clinical problems reported by a lupus patient are due to the disease. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of multifactorial origin that can affect any organ or organ system, resulting in a broad spectrum of clinical manifestations ranging from dermatological involvement to multi-organ failure with episodes of relapses and remissions. , Urowitz MB 25 (FIVE YEARS 8) Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords Latest Documents; Most Cited Documents; Contributed Authors; Related Sources; , Perez-Gutthann S , Urowitz MB. et al. Stojan G Mahler M Methods This SLR was conducted by two independent reviewers in accordance with the PRISMA statement. et al. Mok CC Parodis I Franklyn K , Urowitz MB. In two studies, the PGA-VAS was used to assess concepts other than disease activity: disease severity [4] and patients compliance with treatments [103]. The SRI is a validated SLE disease activity instrument used to detect clinically meaningful improvement of disease in SLE clinical trials. The company serves physicians and patients. , Mohan C. Jolly M Help us improve CareerBuilder by providing feedback about this job: Report this job Job ID: 2281236908. Conclusion: BILAGAB . , Aggarwal R , Gomez A Methods Patients attending a rheumatology clinic between 2013 and 2017 completed specific (SLEQOL) and generic (SF36) health-related quality of life (HRQoL) surveys and rated . This enabled the PGA to be considered the gold standard in several studies [2, 10, 11, 21, 23, 49, 67, 76, 78, 84, 88]. et al. , Ibanez D , Kharboutli M Objectives Remission in systemic lupus erythematosus (SLE) is defined through a combination of 'clinical SLE Disease Activity Index (cSLEDAI)=0', 'physician's global assessment (PGA) <0.5 . The .gov means its official. Epub 2014 Apr 11. T2 - A longitudinal study. In 16 studies the PGA was used as a mean to assess changes in disease activity after treatment [3, 12, 22, 29, 40, 42, 43, 52, 54, 56, 57, 80, 85, 87, 95, 98, 101]. , Ko T The sensitivity to change was estimated to be the smallest for the SLEDAI; the standardized response means were 0.48 when the physician global assessment was used as the standard and 0.01 when the patient global assessment was used . Construct validity was demonstrated by a good correlation (r0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). Once two investigators (E.C., M.P.) , Engel SM , McGwin G One study showed a significant ability of the PGA in distinguishing between patients (P<0.0001) and observers (P<0.0001), but not between visits [79]. , Sato JO Rheumatology (Oxford). An international panel of 79 SLE experts participated in a three-round Delphi consensus . Accessibility Direkt zum Inhalt springen . The interrater reliability (interRR) of the PGA is the ability to provide consistent scores in a stable population between two or more physicians who evaluate the disease activity of the same patient.

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